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Study on Hypoxia Induced the Expression of CCNE2 by HIF-2α(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2014年02期
Page:
96-
Research Field:
生命科学
Publishing date:

Info

Title:
Study on Hypoxia Induced the Expression of CCNE2 by HIF-2α
Author(s):
Zou Yang; Wang Wei; Wen Chuanjun
School of Life Sciences,Nanjing Normal University,Jiangsu Key Laboratory for Molecular and Medical Biotechnology,Nanjing 210023,China
Keywords:
hypoxia; MCF-7; HIF-2α; CCNE2
PACS:
Q291
DOI:
-
Abstract:
Hypoxia is one of the process of tumorigenesis and tumor metastasis,it promotes the expression of tumors which promotes tumor cells distant metastasis. Hypoxia plays an important role in EMT process, which stimulates the degradation and metastasis of tumor,moreover,it promotes the expression of vascular activator to induce the formation of tumor blood vessels. As a key regulating in cell cycle genes,the role of CCNE2 in tumorigenesis and metastasis has been extensively studied,CCNE2 is found to express more than normal cells in various cancer cells. For these,a series of ex- periments are done to demonstrate CCNE2 is a new target to hypoxia and hypoxia induces the expression of CCNE2 by HIF-2α.

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Last Update: 2014-06-30