|Table of Contents|

Computational Investigation of Adsorption Behaviors of Human Fibrinopeptide Segment at Different Polymer Material Surfaces(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2015年02期
Page:
49-
Research Field:
化学
Publishing date:

Info

Title:
Computational Investigation of Adsorption Behaviors of Human Fibrinopeptide Segment at Different Polymer Material Surfaces
Author(s):
Wu Yun1; 2; Xu Wang3; Ding Hongyan2; Shao Kefeng3; Zhao Bo3
(1.Department of Physical Chemistry,College of Science,China Pharmaceutical University,Nanjing 211198,China) (2.Jiangsu Provincial Key Laboratory for Interventional Medical Devices,Huaiyin Institute of Technology,Huaian 223003 China) (3.Jiangsu Key Laboratory of Biofunctional Materials,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China)
Keywords:
anticoagulative polymer material; fibrinopeptide segment; physical adsorption; molecular simulation
PACS:
TB34
DOI:
-
Abstract:
Since the adsorption behaviors of the peptides at material surfaces play an important role in many research fields and simulation studies can provide deep insights into more interaction details of the adsorption behaviors. A molecular simulation is performed using Materials Studio 4.4(MS 4.4)software package to investigate the physical adsorption behavior of the fibrinopeptide segment(HFG)separated from fibrinopeptide,which is the most important protein in the processes of hemeostasis and thrombosis,at three different kinds of polymeric biomaterials— polytetrafluoroethylene(PTFE),polyvinyl chloride(PVC),and Silicone Rubber(SR). The results suggest that the adsorption of HFG is weaker and weaker with the hydrophobicity increasing of the materials surfaces. The hydrophobic PTFE polymer materials show the best behavior to prevent the adsorption while the significant adsorption of HFG on the Silicon Rubber surface occur. Moreover,water also plays a promoting role to the interaction properties between the HFG and the polymer materials. The existence of water is strongly tend to take the peptide molecule away form the adsorption surface.

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Last Update: 2015-06-30