[1]HeY,ZhengR,LiD,etal.PancreaticcancerincidenceandmortalitypatternsinChina,2011[J].ChineseJournalofCancerResearch,2015,27(1):29.
[2]TangSC,ChenYC.Noveltherapeutictargetsforpancreaticcancer[J].WorldJournalofGastroenterology:WJG,2014,20(31):10825.
[3]GongK,ChenC,ZhanY,etal.Autophagy-relatedgene7(ATG7)andreactiveoxygenspecies/extracellularsignal-regulatedkinaseregulatetetrandrine-inducedautophagyinhumanhepatocellularcarcinoma[J].JBiolChem,2012,287(42):35576-35588.
[4]MeiL,ChenY,WangZ,etal.Synergisticanti-tumoureffectsoftetrandrineandchloroquinecombinationtherapyinhumancancer:apotentialantagonisticroleforp21[J].BrJPharmacol,2015,172(9):2232-2245.
[5]BaekKH,ParkJ,ShinI.Autophagy-regulatingsmallmoleculesandtheirtherapeuticapplications[J].ChemSocRev,2012,41(8):3245-3263.
[6]LiY,LuoP,WangJ,etal.AutophagyblockadesensitizestheanticanceractivityofCA-4viaJNK-Bcl-2pathway[J].ToxicologyandAppliedPharmacology,2014,274(2):319-327.
[7]HanMW,LeeJC,ChoiJY,etal.AutophagyinhibitioncanovercomeradioresistanceinbreastcancercellsthroughsuppressionofTAK1activation[J].AnticancerResearch,2014,34(3):1449-1455.
[8]LorinS,Hama?A,MehrpourM,etal.Autophagyregulationanditsroleincancer[C]//SeminarsinCancerBiology.Manhattan,NewYork:AcademicPress,2013.
[9]SteevesMA,DorseyFC,ClevelandJL.Targetingtheautophagypathwayforcancerchemoprevention[J].CurrentOpinioninCellBiology,2010,22(2):218-225.
[10]CarewJS,NawrockiST,ClevelandJL.Modulatingautophagyfortherapeuticbenefit[J].Autophagy,2007,3(5):464-467.
[11]RubinszteinDC,GestwickiJE,MurphyLO,etal.Potentialtherapeuticapplicationsofautophagy[J].NatureReviewsDrugDiscovery,2007,6(4):304-312.
[12]LiD,XieK,WolffR,etal.Pancreaticcancer[J].TheLancet,2004,363(9414):1049-1057.
[13]JemalA,SiegelR,XuJ,etal.Cancerstatistics,2010[J].CA:ACancerJournalforClinicians,2010,60(5):277-300.
[14]YangS,WangX,ContinoG,etal.Pancreaticcancersrequireautophagyfortumorgrowth[J].Genes&Development,2011,25(7):717-729.
[15]KangR,TangD,SchapiroNE,etal.Thereceptorforadvancedglycationendproducts(RAGE)sustainsautophagyandlimitsapoptosis,promotingpancreatictumorcellsurvival[J].CellDeath&Differentiation,2010,17(4):666-676.
[16]FujiiS,MitsunagaS,YamazakiM,etal.Autophagyisactivatedinpancreaticcancercellsandcorrelateswithpoorpatientoutcome[J].CancerScience,2008,99(9):1813-1819.
[17]ZhuR,LiuT,TanZ,etal.Tetrandrineinducesapoptosisingallbladdercarcinomainvitro[J].InternationalJournalofClinicalPharmacologyandTherapeutics,2014,52(10):900-905.
[18]ChenLM,LiangYJ,ZhangX,etal.ReversalofP-gp-mediatedmultidrugresistancebyBromotetrandrineinvivoisassociatedwithenhancedaccumulationofchemotherapeuticaldrugintumortissue[J].AnticancerRes,2009,29(11):4597-4604.
[19]LiX,SuB,LiuR,etal.TetrandrineinducesapoptosisandtriggersCaspasecascadeinhumanbladdercancercells[J].JSurgRes,2011,166(1):e45-e51.
[20]LiuC,GongK,MaoX,etal.TetrandrineinducesapoptosisbyactivatingreactiveoxygenspeciesandrepressingAktactivityinhumanhepatocellularcarcinoma[J].InternationalJournalofCancer,2011,129(6):1519-1531.
[21]WangH,LiuT,LiL,etal.Tetrandrineisapotentcellautophagyagonistviaactivatedintracellularreactiveoxygenspecies[J].Cell&Bioscience,2015,5(1):4-12.
[22]LeeBS,KangS,KimKA,etal.MetdegradationbySAIT301,aMetmonoclonalantibody,reducestheinvasionandmigrationofnasopharyngealcancercellsviainhibitionofEGR-1expression[J].CellDeath&Disease,2014,5(4):e1159.
[23]SunS,NingX,ZhaiY,etal.Egr-1mediateschronichypoxia-inducedrenalinterstitialfibrosisviathePKC/ERKpathway[J].AmericanJournalofNephrology,2014,39(5):436-448.