[1]杨 超,马 菲,唐 静,等.新型竹红菌甲素与钒氧离子配合物的制备及光敏性质研究[J].南京师大学报(自然科学版),2013,36(01):64-67.
　Yang Chao,Ma Fei,Tang Jing,et al.Preparation of a New Hypocrellin A-vanadyl(VO2+-HA)Complex and Its Photosensitive Property Studies[J].Journal of Nanjing Normal University(Natural Science Edition),2013,36(01):64-67.
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新型竹红菌甲素与钒氧离子配合物的制备及光敏性质研究()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第36卷
期数:
2013年01期
页码:
64-67
栏目:
化学
出版日期:
2013-03-31

文章信息/Info

Title:
Preparation of a New Hypocrellin A-vanadyl(VO2+-HA)Complex and Its Photosensitive Property Studies
作者:
杨 超1; 2; 马 菲3; 唐 静1; 2; 韩丽娜1; 2; 魏少华2; 周 林2; 周家宏1; 2;  沈 健2; 葛学峰1
(1.南京师范大学分析测试中心,江苏 南京 210023) (2.江苏省生物功能材料重点实验室,江苏 南京 210023) (3.南京师范大学地理科学学院,江苏 南京 210023)
Author(s):
Yang Chao1; 2; Ma Fei3; Tang Jing1; 2; Han Lina1; 2; Wei Shaohua2; Zhou Lin2; Zhou Jiahong1; 2;  Shen Jian2; Ge Xuefeng1
(1.Analysis and Testing Center,Nanjing Normal University,Nanjing 210023,China) (2.Key Laboratory of Biofunctional Materials of Jiangsu Province,Nanjing 210023,China) (3.School of Geography Science,Nanjing Normal University,Nanjing 210023,China)
关键词:
竹红菌甲素-钒氧配合物; 单线态氧; 光敏损伤; CT DNA
Keywords:
hypocrellin A-vanadyl complex; singlet oxgen; photodamage; CT DNA
分类号:
O657
摘要:
采用紫外-可见吸收光谱和荧光光谱系统研究了竹红菌甲素和钒氧离子之间的相互作用,实验结果表明,与竹红菌甲素相比,新型配合物的紫外光谱吸收峰红移且吸收峰强度增加,荧光强度降低,具有一定的光敏产生单线态氧及光敏损伤CT DNA的能力.采用透射电镜对其粒径大小进行测定,结果表明纳米粒的平均粒径在60 nm左右,单分散性质良好.因此,该配合物的形成将进一步推动竹红菌甲素在光动力疗法中的应用.
Abstract:
The interaction between hypocrellin A(HA)and vanadyl(VO2+)was analyzed by UV-Vis and fluorescence spectra.The experiments results showed that HA and VO2+ can form a stable complex in aqueous solution.The complex exhibited obvious red shift,decreased absorbance and fluorescence intensity.Also,it possessed the ability of produce singlet oxygen and photodamage CT DNA.Then,the TEM was used to obtain the grain diameter of the new complex.The particle with mid-diameter of 60 nm was clearly observed.So the synthesis of the complex can further promote the application of HA in photodynamic treatment.

参考文献/References:

[1] 刘岩岩,王雪松,张宝文.竹红菌素类光动力药物[J].化学进展,2008,20(9):1 345-1 352.
[2]徐尚杰.新型光动力药物-竹红菌甲素衍生物的研究与进展[J].科学通报,2003,48(10):1 005-1 015.
[3]Zeng Z H,Zhou J H,Zhang Y,et al.Photodynamic properties of hypocrellin A,complexes with rare earth trivalent ions:role of the excited state energies of the metal ions[J].J Phys Chem B,2007,111(10):2 688-2 696.
[4]Zhou J H,Xia S Q,Chen J R,et al.The photodynamic property improvement of hypoctellin A by chelation with lanthanum ions[J].Chem Comm,2003:1 372-1 373.
[5]Ghosh P,Dcruz O J,Narla R K,et al.Apoptosis-inducing vanadocene compounds against human testicular cancer[J].Clin Cancer Res,2000,6(4):1 536-1 545.
[6]Evangelou A,Karkabounas S,Kalpouzos G,et al.Comparison of the therapeutic effects of two vanadium complexes administered at low dose on benzo pyrene-induced malignant tumors in rats[J].Cancer Lett,1997,119(2):221-225.
[7]Krejsa C M,Nadler S G,Esselstyn J M,et al.Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors.Redox independent activation of NF-κB[J].J Biol Chem,1997,272(17):11 541-11 549.
[8]Sun Y,Zheng Y,Lei W H,et al.Oxovanadium(Ⅳ)based hypocrellin B complexes with enhanced photodynamic activity[J].Dalton Trans,2012,41:651-657.
[9]Yan F,Kopelman R.The embedding ofmeta-tetra(hydroxyphenyl)-chlorin into silica nanoparticle platforms for photodynamic therapy and their singletoxygen production and pH-dependent optical properties[J].Photochem and Photobiol,2003,78(6):587-591.
[10]Tang W,Xu H,Kopelman R,et al.Photodynamic characterization and in vitro application of methylene blue-containing nanoparticle platforms[J].Photochem and Photobiol,2005,81(2):242-249.
[11]Yang C,Ma F,Tang J,et al.Synthesis of vanadyl-hypocrellin A complex and its photodynamic properties research[J].Bioorg Med Chem Lett,2012,22:5 003-5 007.

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备注/Memo

备注/Memo:
收稿日期:2012-04-20.
基金项目:江苏高校自然科学基金(10KJB150008)..
通讯联系人:周林,博士,讲师,研究方向:光动力疗法.E-mail:zhoulin@njnu.edu.cn
更新日期/Last Update: 2013-03-31