[1]李伟丽,陈梦玲,李国梁,等.生后发育早期甜味经历影响老年甜味偏好[J].南京师大学报(自然科学版),2013,36(04):100.
 Li Weili,Chen Mengling,Li Guoliang,et al.Age-Related Changes of Sweet Taste Preference is Modified by Early Sweet Experience[J].Journal of Nanjing Normal University(Natural Science Edition),2013,36(04):100.
点击复制

生后发育早期甜味经历影响老年甜味偏好
分享到:

《南京师大学报(自然科学版)》[ISSN:1001-4616/CN:32-1239/N]

卷:
第36卷
期数:
2013年04期
页码:
100
栏目:
生命科学
出版日期:
2013-12-31

文章信息/Info

Title:
Age-Related Changes of Sweet Taste Preference is Modified by Early Sweet Experience
作者:
李伟丽1陈梦玲2李国梁1刘斯斯2梁 沛2詹月华2张根华12
(1.苏州大学医学部基础医学与生物科学学院,江苏 苏州 215123) (2.常熟理工学院食品与生物工程学院,江苏 常熟 215500)
Author(s):
Li Weili1Chen Mengling2Li Guoliang1Liu Sisi2Liang Pei2 Zhan Yuehua2Zhang Genhua12
(1.College of Preclinical Medicine and Biological Science,Soochow University,Suzhou 215123,China) (2.College of Biology and Food Engineering,Changshu Institute of Technology,Changshu 215500,China)
关键词:
甜味早期经历衰老抑制偏好
Keywords:
sweet tasteearly experienceaginginhibitionpreference
分类号:
Q189
文献标志码:
A
摘要:
哺乳期给予母鼠不同浓度AK糖饮水暴露,子代小鼠通过母鼠乳汁获得AK味觉经历.子鼠成年后分别在2个月和12个月大时,双管喜好测试检测小鼠对AK糖溶液的偏好变化.结果显示,早期高浓度的甜味剂经历提高了小鼠成年和老年时AK偏好阈值,降低了小鼠老年时在阈值附近浓度上的偏好分数; 同时早期AK经历抑制了正常小鼠在衰老过程中甜味偏好的下降.因此,早期味觉经历影响小鼠在成年和老年时期的甜味偏好,并在一定程度上影响小鼠在衰老过程中的甜味偏好变化.
Abstract:
Mice were exposed to acesulfame-K(AK)via maternal milk from the mother mice during lactation,and two-bottle preference tests for AK solution were performed in 2 and 12 months old.Results indicated that early strong intensity of sweet tastant experience increased the preference threshold and induced a reduction of preference scores about preference thershold at aged stage.Meanwhile,early AK experience inhibited the decrease of preference scores as that in the control animals during the advanced aging.Therefore early taste experience influence the sweet preference at adult and aged stage and modify the sweet preference during the aging process.

参考文献/References:

[1] Schiffman S S.Perception of taste and smell in elderly persons[J].Crit Rev Food Sci Nutr,1993,33(1):17-26.
[2]Schiffman S S.Effects of aging on the human taste system[J].Ann N Y Acad Sci,2009,1 170:725-729.
[3]Methven L,Allen V J,Withers C A,et al.Aging and taste[J].Proc Nutr Soc,2012,71(4):556-565.
[4]Cowart B J,Yokomukai Y,Beauchamp G K.Bitter taste in aging:compound-specific decline in sensitivity[J].Physiol Behav,1994,56(6):1 237-1 241.
[5]Fukunaga A,Uematsu H,Sugimoto K.Influences of aging on taste perception and oral somatic sensation[J].J Gerontol A Biol Sci Med Sci,2005,60(1):109-113.
[6]Shin Y K,Cong W N,Cai H,et al.Age-related changes in mouse taste bud morphology,hormone expression,and taste responsivity[J].J Gerontol A Biol Sci Med Sci,2012,67(4):336-344.
[7]Toffanello E D,Inelmen E M,Minicuci N,et al.Ten-year trends in dietary intake,health status and mortality rates in free-living elderly people[J].J Nutr Health Aging,2010,14(4):259-264.
[8]Beauchamp G K,Mennella J A.Flavor perception in human infants:development and functional significance[J].Digestion,2011,83(Suppl 1):1-6.
[9]Cooke L,Fildes A.The impact of flavour exposure in utero and during milk feeding on food acceptance at weaning and beyond[J].Appetite,2011,57(3):808-811.
[10]Mennella J A,Jagnow C P,Beauchamp G K.Prenatal and postnatal flavor learning by human infants[J].Pediatrics,2001,107(6):e88-e90.
[11]Bernstein I L,Fenner D P,Diaz J.Influence of taste stimulation during the suckling period on adult taste preference in rats[J].Physiol Behav,1986,36(5):913-919.
[12]Sato N,Shimizu H,Shimomura Y,et al.Sucrose feeding at weaning alters the preference for sucrose in adolescence[J].Exp Clin Endocrinol,1991,98(3):201-206.
[13]Ueji K,Yamamoto T.Flavor learning in weanling rats and its retention[J].Physiol Behav,2012,106(4):417-422.
[14]Renteria A F,Silbaugh B C,Tolentino J C,et al.Age-related changes in conditioned flavor preference in rats[J].Behav Brain Res,2008,188(1):56-61.
[15]Zhang G H,Chen M L,Liu S S,et al.Effects of mother’s dietary exposure to acesulfame-K in Pregnancy or lactation on the adult offspring’s sweet preference[J].Chem Senses,2011,36(9):763-770.
[16]Bachmanov A A,Li X,Reed D R,et al,Positional cloning of the mouse saccharin preference(Sac)locus[J].Chem Senses,2001,26:925-933.
[17]Li W L,Chen M L,Liu S S,et al.Sweet preference modified by early experience in mice and the related molecular modulations on the peripheral pathway[J].J Mol Neurosci,2013,51(1):225-236.
[18]Bachmanov A A,Tordoff M G,Beauchamp G K.Sweetener preference of C57BL/6ByJ and 129P3/J mice[J].Chem Senses,2001,26(7):905-913.
[19]Myers K P,Hall W G.Evidence that oral and nutrient reinforcers differentially condition appetitive and consummatory responses to flavors[J].Physiol Behav,1998,64(4):493-500.
[20]Myers K P,Ferris J,Sclafani A.Flavor preferences conditioned by postin gestive effects of nutrients in preweanling rats[J].Physiol Behav,2005,84(3):407-419.
[21]Weiffenbach J M,Baum B J,Burghauser R.Taste thresholds:quality specific variation with human aging[J].J Gerontol,1982,37(3):372-377.
[22]Murphy C,Gilmore M M.Quality-specific effects of aging on the human taste system[J].Percept Psychophys,1989,45(2):121-128.
[23]Gaillard D,Barlow L A.Taste bud cells of adult mice are responsive to Wnt/beta-catenin signaling:implications for the renewal of mature taste cells[J].Genesis,2011,49(4):295-306.

备注/Memo

备注/Memo:
收稿日期:2013-03-08.
基金项目:国家自然科学
基金项目资助(NSFC31200812).
通讯联系人:张根华,教授,博士,研究方向:食品感官科学.E-mail:zgh@cslg.cn
更新日期/Last Update: 2013-12-30