[1]唐娅秋,朱亚男,王美菊,等.姬菇多糖对免疫低下型小鼠肝脏和肾脏抗氧化作用的影响[J].南京师范大学学报(自然科学版),2019,42(04):85-90.[doi:10.3969/j.issn.1001-4616.2019.04.012]
　Tang Yaqiu,Zhu Yanan,Wang Meiju,et al.Effects of Acid Polysaccharides from Pleurotus cornucopiaeon the Antioxidation in Mice with Immunosuppression[J].Journal of Nanjing Normal University(Natural Science Edition),2019,42(04):85-90.[doi:10.3969/j.issn.1001-4616.2019.04.012]
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姬菇多糖对免疫低下型小鼠肝脏和肾脏抗氧化作用的影响()
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《南京师范大学学报》（自然科学版）[ISSN:1001-4616/CN:32-1239/N]

卷:
第42卷
期数:
2019年04期
页码:
85-90
栏目:
·生命科学·
出版日期:
2019-12-30

文章信息/Info

Title:
Effects of Acid Polysaccharides from Pleurotus cornucopiaeon the Antioxidation in Mice with Immunosuppression
文章编号:
1001-4616(2019)04-0085-06
作者:
唐娅秋; 朱亚男; 王美菊; 徐菘阳; 李 强; 陶明煊
南京师范大学食品与制药工程学院,江苏 南京 210097
Author(s):
Tang Yaqiu; Zhu Yanan; Wang Meiju; Xu Songyang; Li Qiang; Tao Mingxuan
School of Food Science and Pharmaceutical Engineering,Nanjing Normal University,Nanjing 210097,China
关键词:
姬菇多糖; 肝脏; 肾脏; 抗氧化; 免疫
Keywords:
APPC; liver; kidney; antioxidant; immune
分类号:
TS201.4
DOI:
10.3969/j.issn.1001-4616.2019.04.012
文献标志码:
A
摘要:
以姬菇的酸性多糖成分(APPC)为试验材料,建立环磷酰胺诱导的免疫抑制小鼠模型,测定相关抗氧化指标,探究APPC对小鼠肝脏、肾脏免疫活性作用的影响. 将72只小鼠随机分为空白组、阳性组、模型组以及APPC高、中、低不同剂量组. 通过检测各组肝脏和肾脏中超氧化物歧化酶(SOD)活性、谷胱甘肽氧化物酶(GSH-Px)活性、过氧化氢酶(CAT)活性、谷胱甘肽(GSH)含量和丙二醛(MDA)含量5项抗氧化指标,考察肝脏、肾脏功能免疫特性的变化. 与模型对照组相比,APPC可以显著提高肝脏和肾脏的SOD活性、GSH
Abstract:
By using acid polysaccharides from Pleurotus cornucopiae(APPC)as a test material,we established a cyclophosphamide-induced immunosuppressive mouse model and determine the relevant antioxidant index to explore the effect of APPC on the immune activity of liver and kidney in mice. The 72 mice were randomly divided into normal control group,model group,positive control group,as well as high,medium and low APPC dosage group. And by detecting the following antioxidant indexes,including superoxide dismutase(SOD)activity,glutathione(GSH)content,glutathione peroxidase(GSH-Px)activity,catalase(CAT)activity and malondialdehyde(MDA)content,the results could investigate the changes of liver and kidney function characteristics. Compared with the model group,APPC significantly increased SOD activity,GSH-Px activity,CAT activity and GSH content in liver and kidney(P<0.01),and decreased MDA content in liver and kidney(P<0.01). This implies that APPC has a certain improving effect on the immune function of the immune-inhibited mice liver,while betters the immune regulation ability of kidney.

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备注/Memo

备注/Memo:
收稿日期:2018-12-19.
基金项目:宁波市公益类科技计划项目(2019C10096).
通讯联系人:陶明煊,硕士,副教授,研究方向:生物活性物质与保健功能因子. E-mail:45017@njnu.com
更新日期/Last Update: 2019-12-31