[1]盛 玥,李 钢.抗癌药Imatinib Mesylate的多晶型结构与稳定性[J].南京师大学报(自然科学版),2014,37(01):137.
　Sheng Yue,Li Gang.Study on Polymorphism and Stability of Anticancer Drug Imatinib Mesylate[J].Journal of Nanjing Normal University(Natural Science Edition),2014,37(01):137.
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抗癌药Imatinib Mesylate的多晶型结构与稳定性()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第37卷
期数:
2014年01期
页码:
137
栏目:
生命科学
出版日期:
2014-03-30

文章信息/Info

Title:
Study on Polymorphism and Stability of Anticancer Drug Imatinib Mesylate
作者:
盛 玥; 李 钢
南京师范大学分析测试中心,江苏 南京 210023
Author(s):
Sheng Yue; Li Gang
Analysis and Testing Center,Nanjing Normal University,Nanjing 210023,China
关键词:
甲磺酸伊马替尼; X射线粉末衍射; 多晶型
Keywords:
imatinib mesylate; X-ray powder diffraction; polymorphism
分类号:
R917
文献标志码:
A
摘要:
本文对抗癌药物甲磺酸伊马替尼的多晶型与稳定性进行了分析与研究.通过X射线粉末衍射仪(XRD)测定了伊马替尼的晶型,并测定了在不同湿度下的稳定性,用X射线衍射原位高温附件(in situ high temperature)测定了伊马替尼的热稳定性.结果表明,该批次伊马替尼为α晶型,在从室温至200 ℃的加热过程中晶体结构稳定,在RH 75%的湿度条件下,结构也比较稳定,但在RH 92.5%的高湿度时,晶体结构逐渐向无定形转化.
Abstract:
This article studies the stability and the crystal structure of an anticancer drug imatinib mesylate.The crystal form of the imatinib mesylate was determined by means of X-ray powder diffraction.The stability under different humidity was determined and the thermostability of imatinib mesylate was analyzed by X-ray diffraction(XRD)with in situ high temperature accessories.The results showed that the sample is the α crystalline form and its crystal form was stable during the heating process from room temperature to 200 ℃.The crystal form was stable under low humidity,but unstable under high humidity and finally turned to amorphous.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2013-04-23.
基金项目:江苏省生物医药材料测试服务平台项目(BM2007132)、江苏省自然科学基金(BK2001111).
通讯联系人:李钢,教授,研究方向:药物多晶型研究.E-mail:ligang1@njnu.edu.cn
更新日期/Last Update: 2014-03-30