[1]杨 倩,臧欣欣,吴 婧,等.1-氰基-中氮茚-3-[N-(2-氨基乙基)]甲酰胺的合成及其Cu2+荧光探针行为[J].南京师大学报(自然科学版),2015,38(02):65.
　Yang Qian,Zang Xinxin,Wu Jing,et al.Studies on Synthesis of 1-Cyano-indolizine-3-[N-(2-aminoethyl)] Carboxamide and Its Application as Fluorescent Sensors for Cu2+[J].Journal of Nanjing Normal University(Natural Science Edition),2015,38(02):65.
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1-氰基-中氮茚-3-[N-(2-氨基乙基)]甲酰胺的合成及其Cu2+荧光探针行为()
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《南京师大学报》（自然科学版）[ISSN:1001-4616/CN:32-1239/N]

卷:
第38卷
期数:
2015年02期
页码:
65
栏目:
化学
出版日期:
2015-06-30

文章信息/Info

Title:
Studies on Synthesis of 1-Cyano-indolizine-3-[N-(2-aminoethyl)] Carboxamide and Its Application as Fluorescent Sensors for Cu2+
作者:
杨 倩1; 臧欣欣1; 吴 婧2; 王炳祥1
(1.江苏省生物功能材料重点实验室,江苏省生物医药功能材料工程研究中心,南京师范大学化学与材料科学学院,江苏 南京 210023) (2.中国药科大学国际医药商学院,江苏 南京 211198)
Author(s):
Yang Qian1; Zang Xinxin1; Wu Jing2; Wang Bingxiang1
(1.Jiangsu Key Laboratory of Biofunctional Materials,Jiangsu Research Center of Biomedical Functional Materials Engineering, School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China) (2.School of International Pharmaceutical Business,China Pharmaceutical University,Nanjing 211198,China)
关键词:
1-氰基-中氮茚-3-[N-(2-氨基乙基)]甲酰胺; Cu2+; 荧光探针
Keywords:
1-cyano-indolizine-3-[N-(2-aminoethyl)]carboxamide; Cu2+; fluorescence probes
分类号:
O626
文献标志码:
A
摘要:
设计合成了1-氰基-中氮茚-3-[N-(2-氨基乙基)]甲酰胺(化合物3). 通过IR,1H NMR对其结构进行了表征,测试了其紫外光谱和荧光光谱,研究了其对Cu2+、Zn2+、Ni2+、Co2+、Mg2+、Na+、K+和Ca2+的识别作用,发现Zn2+、Ni2+、Co2+、Mg2+、Na+、K+和Ca2+对化合物3的荧光光谱几乎没有影响,但Cu2+对化合物3有非常强大亲和力,Cu2+可以使化合物3的荧光发射明显猝灭,化合物3在DMSO溶剂中作为铜离子荧光探针,受常见离子干扰较小,对于铜离子有着较高的选择性.
Abstract:
We report here the synthesis of 1-cyano-indolizine-3-[N-(2-aminoethyl)]carboxamide(No.3 compound)and the study of it as fluorescent probe for Cu2+ ions. The structure of the compound 3 was determined by IR,1H NMR. Its UV and fluorescence spectra were measured. The influences of eight metal ions such as Cu2+,Zn2+,Ni2+,Co2+,Mg2+,Na+,K+and Ca2+ on its fluorescence property was studied. Spectroscopic study revealed that the compound 3 had rather strong affinity toward Cu2+. The specificity of the compound 3 toward Cu2+was determined. Nearly no fluorescence intensity changes were observed in emission spectra with Zn2+,Ca2+,Na+,K+,Mg2+but Ni2+ and Co2+. However,under identical conditions,the study showed fluorescence quenching from Cu2+. So we have developed a new fluorescent sensor. It showed high selectivity toward Cu2+ in DMSO.

参考文献/References:

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相似文献/References:

[1]周乐山,史雪严,杨梦娇,等.基于L-苯丙氨酸一步水热合成碳量子点及其对Cu2+的检测[J].南京师大学报(自然科学版),2016,39(02):147.[doi:10.3969/j.issn.1001-4616.2016.02.025]

备注/Memo

备注/Memo:
收稿日期:2014-04-03.
基金项目:2013年地方高校国家级大学生创新创业训练计划项目、江苏省高等学校大学生实践创新训练计划项目.
通讯联系人:吴婧,博士,讲师,研究方向:药物化学. E-mail:nswujing@163.com
更新日期/Last Update: 2015-06-30