参考文献/References:
［1］ KMC C，Hudock M P，Zhang Y，et al． Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation［J］． J Med Chem， 2008，51( 18) : 5 594-5 607．
［2］ Casey P J，Seabra M C． Protein prenyltransferases［J］． Journal of Biological Chemistry，1996，271( 10) : 5 289-5 292．
［3］ Ericsson J，Greene J M，Carter K C，et al． Human geranylgeranyl diphosphate synthase: isolation of the cDNA，chromosomal mapping and tissue expression［J］． J Lipid Res，1998，39( 9) : 1 731-1 739．
［4］ Shen N，Gong T，Wang J D，et al． Cigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1 /GGPPS /MAPK signaling［J］． American Journal of Pathology，2011，178( 1) : 110-118．
［5］ Choi K L，Aldrich R W，Yellen G． Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K + channels［J］． Proc Natl Acad Sci，1991，88( 12) : 5 092-5 095．
［6］ Friedman S L． Hepatic stellate cells: Protean，multifunctional，and enigmatic cells of the liver［J］． Physiological Reviews， 2008，88( 1) : 125-172．
［7］ Xu L，Hui A Y，Albanis E，et al． Human hepatic stellate cell lines，LX － 1 and LX － 2: new tools for analysis of hepatic fibrosis ［J］． Gut，2005，54( 1) : 142-151．
［8］ Boguski M S，Mccormick F． Proteins regulating ras and its relatives［J］． Nature，1993，366( 6456) : 643-654．
［9］ 赵寿元，赵余龙，高洁，等． 人牻牛儿基牻牛儿基焦磷酸合成酶的cDNA 克隆基因定位及组织表达谱分析［J］． 中国科学C 辑， 2000，30( 5) : 467-474．
［10］ Yoshida T，Asanuma M，Grossmann L，et al． Geranylgeranyl-pyrophosphate ( GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1［J］． Febs Letters，2006，580( 22) : 5 203-5 207．
［11］ 何金生，王健伟，涛洪． 腺病毒载体构建原理与方法的研究进展［J］． 中华实验和临床病毒学，2001，15( 4) : 399- 400．
［12］ 卢大儒，邱信芳． 腺病毒载体、腺病毒相关病毒载体与基因治疗［J］． 国外医学: 遗传学，1995，18( 2) : 61-64．
［13］ Povero D，Busletta C，Novo E，et al． Liver fibrosis: a dynamic and potentially reversible process［J］． Histol Histopathol， 2010，25( 8) : 1 075-1 091．
［14］ Margadant C，Sonnenberg A． Integrin-TGF-beta crosstalk in fibrosis，cancer and wound healing［J］． EMBO Rep，2010，11 ( 2) : 97-105．
［15］ Jiao J，Friedman S L，Aloman C． Hepatic fibrosis［J］． Curr Opin Gastroenterol，2009，25( 3) : 223-229．
［16］ Breitkopf K，Roeyen C，Sawitza I，et al． Expression patterns of PDGF-A，-B，-C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells ( HSC) ［J］． Cytokine，2005，31( 5) : 349-357．
［17］ Kitamura K，Tada S，Nakamoto N，et al． Rho /Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis［J］． Journal of Gastroenterology and Hepatology，2007，22( 1) : 2 022-2 033．
［18］ Murata T，Arii S，Mori A，et al． Therapeutic significance of Y-27632，a Rho-kinase inhibitor，on the established liver fibrosis ［J］． Journal of Surgical Research，2003，114( 1) : 64-71．
［19］ Tada S，Iwamoto H，Nakamuta M，et al． A selective ROCK inhibitor，Y27632，prevents dimethylnitrosamine-induced hepatic fibrosis in rats［J］． Journal of Hepatology，2001，34( 4) : 529-536．
［20］ Wettschureck N，Offermanns S． Rho /Rho-kinase mediated signaling in physiology and pathophysiology［J］． Journal of Molecular Medicine，2002，80( 10) : 629-638．
相似文献/References:
[1]王江南,丁 尧,来珊珊,等.GGPPS多克隆抗体的制备与鉴定[J].南京师大学报(自然科学版),2013,36(01):94.
Wang Jiangnan,Ding Yao,Lai Shanshan,et al.Preparation and Identification of Polyclonal Antibodies of GGPPS[J].Journal of Nanjing Normal University(Natural Science Edition),2013,36(04):94.