[1]潘吉超,姚飞,任腾飞,等.聚(3,4-乙烯基二氧噻吩)/碳纳米管复合膜修饰电极的电化学制备及其用于8-羟基-2\’-脱氧鸟嘌呤核苷的检测[J].南京师大学报(自然科学版),2012,35(02):66-71.
　Pan Jichao,Yao Fei,Ren Tengfei,et al.Electrochemical Preparation of Poly(3,4-Ethylenedioxythiophene)/Carbon Nanotubes Composite Film Modified Electrode and Its Application to Determination of 8-Hydroxy-2′-Deoxyguanosine[J].Journal of Nanjing Normal University(Natural Science Edition),2012,35(02):66-71.
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聚(3,4-乙烯基二氧噻吩)/碳纳米管复合膜修饰电极的电化学制备及其用于8-羟基-2\’-脱氧鸟嘌呤核苷的检测()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第35卷
期数:
2012年02期
页码:
66-71
栏目:
化学
出版日期:
2012-06-20

文章信息/Info

Title:
Electrochemical Preparation of Poly(3,4-Ethylenedioxythiophene)/Carbon Nanotubes Composite Film Modified Electrode and Its Application to Determination of 8-Hydroxy-2′-Deoxyguanosine
作者:
潘吉超;姚飞;任腾飞;贾丽萍;贾文丽;崔慧;王怀生;
聊城大学化学化工学院，山东聊城252059
Author(s):
Pan Jichao; Yao Fei; Ren Tengfei; Jia Liping; Jia Wenli; Cui Hui; Wang Huaisheng
College of Chemistry and Chemical Engineering,Liaocheng University,Liaocheng 252059,China
关键词:
8-羟基-2’-脱氧鸟嘌呤核苷; 聚( 3; 4 -乙烯基二氧噻吩) ; 碳纳米管; 导电聚合物; 尿酸
Keywords:
8-Hydroxy-2’-deoxyguanosine; poly( 3; 4 -ethylenedioxythiophene) ; carbon nanotubes; conductive polymer;  uric acid
分类号:
O657.1
摘要:
通过恒电流电解一步法在玻碳电极表面制备了聚(3,4-乙烯基二氧噻吩)/碳纳米管复合膜,实验结果表明,该复合膜修饰电极综合了聚(3,4-乙烯基二氧噻吩)(PEDOT)和碳纳米管(CNTs)两者的优点,对8-羟基-2’-脱氧鸟嘌呤核苷(8-OH-dG)的氧化具有明显的增强作用,较好地抑制尿酸的干扰,而且具有很好的重现性和稳定性.在0.1 mol/L pH 9.0的磷酸盐缓冲溶液(PBS)中,8-OH-dG的氧化峰电流与其浓度在0.014～14.0μmol/L和14.0～56.0μmol/L两个范围内成良好的线性关系,检出限可达35 nmol/L(S/N=3).
Abstract:
The poly( 3，4-ethylenedioxythiophene) /carbon nanotubes ( CNTs) composite film was prepared on the glassy carbon electrode surface by one-step galvanostatic deposition and used for the study of the electrochemical behavior of 8- hydroxy-2’-deoxyguanosine ( 8-OH-dG) ． The experimental results showed that the hybrid film can combine the advantages of conductivity of PEDOT and the unique electronic performance of CNTs and effectively enhance the adsorption and electrochemical oxidation of 8-OH-dG． Moreover，this proposed hybrid film modified electrode also showed excellent reproducibility and stability in the experiment． In 0. 1 mol /L pH 9. 0 phosphate buffer solution，the oxidative peak currents of 8-OH-dG had two good linear relationships with its concentration in 0. 014 － 14μmol /L and 14 － 56 μmol /L，with the detection limit of 35 nmol /L ( S /N = 3) ．

参考文献/References:

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金( 21075059) 、山东省“泰山学者”建设工程专项经费资助．通讯联系人: 王怀生，教授，博士生导师，研究方向: 生物电分析化学． E-mail: hswang@ lcu． edu． cn
更新日期/Last Update: 2013-03-11