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Pyrimethamine and Chloroquine Reduced Malaria Infected Pregnant BALB/c Mice with Pathology Changes(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2015年02期
Page:
105-
Research Field:
生命科学
Publishing date:

Info

Title:
Pyrimethamine and Chloroquine Reduced Malaria Infected Pregnant BALB/c Mice with Pathology Changes
Author(s):
Peng Lan1; Fan Nengquan2
(1.Foundation Department,Chongqing Medical and Pharmaceutical College,Chongqing 400030,China) (2.Chongqing Institute for Food and Drug Control,Chongqing 400042,China)
Keywords:
malaria; pathology; pyrimethamine; chloroquine
PACS:
R365
DOI:
-
Abstract:
Malaria during pregnancy is closely related to the fetal death,miscarriage,premature delivery and low birth weight in some areas,which are often used to be prevent by pyrimethamine and chloroquine treatment,but the pathological changes in the placenta has not been reported in this study. The purpose is to explore pyrimethamine and chloroquine treatment of pregnant BALB/c mice infected with Plasmodium berghei malaria-induced pathology caused by placenta-like changes. BALB/c mice were randomly divided into 6 groups,the establishment of malaria model,and use of pyrimethamine and chloroquine therapy treatment for malaria infection in the corresponding group of mice survival,oxidation level,apoptosis and histopathological change the situation that were detected and analyzed. After being infected with Plasmodium berghei,the proportion of infected red blood cells was increased significantly(p<0.05),while the survival rate was significantly lower(p<0.05). Pyrimethamine and chloroquine can not only reduce the proportion of infected erythrocytes,but also enhance the survival rate of mice(p<0.05),lipids in mice infected hydrogen peroxide levels and oxidative enzyme levels increased significantly(p<0.05),which was decreased after the treatment of pyrimethamine and chloroquine(p<0.05),while changes in glutathione and superoxide dismutase was not a significant difference(p>0.05),proportion of apoptotic cells in the infected mice,infected red blood cell morphology and pigmentation histopathology increased significantly compared with the uninfected group(p<0.05),the use of pyrimethamine and chloroquine treatment and then decreased significantly(p<0.05). Pyrimethamine and chloroquine in the treatment of malaria by inhibiting oxidative stress and apoptosis occurs,reduce placental histopathological changes,and achieve effective therapeutic purposes.

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Last Update: 2015-06-30