|Table of Contents|

Evolutionary Analysis of SARS-CoV-2 Receptor ACE2Between Humans and Companion Animals(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2020年04期
Page:
62-67
Research Field:
·生物学·
Publishing date:

Info

Title:
Evolutionary Analysis of SARS-CoV-2 Receptor ACE2Between Humans and Companion Animals
Author(s):
Ali Mayan; Huang Ying
School of Life Sciences,Nanjing Normal University,Nanjing 210023,China
Keywords:
COVID-19; ACE2; cross-infection; companion animals
PACS:
Q931
DOI:
10.3969/j.issn.1001-4616.2020.04.010
Abstract:
Since the COVID-19 caused by SARS-CoV-2 discoved and reported,scientists from all over the world have paid tremendous efforts to research and try to control the disease. Previous studies suggested that some of the wild animals could be intermediate hosts between humans and origination of SARS-CoV-2,and some companion animals of humans can be infected by SARS-CoV-2,which raised our curiosity about cross-infection of SARS-CoV-2 between animals and humans. Thus,the study select some kinds of animals that might have contacted with humans to estimate the susceptibility to SARS-CoV-2 in different animals by evolutionary analysis of their receptors for SARS-CoV-2. The results show that some companion animals of the Felidae family like the cat has a higher infection possibility while the species of the Rodent family like the rat and mouse having close contact with humans show an opposite result,which consist with recent animal experiments and researches. These should raise concerns about cross-infection between human and companion animals or animals having close contact with humans which might turn animals into depositaries of the coronavirus even after control of SARS-CoV-2 spreading and cause second or more waves of infections after social reopening. Another side of the results stands by the opinion that bioinformatic analysis can be consistent with experiments in some respects so that we can prevent unnecessary sacrifice of laboratory animals in future experiments.

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Last Update: 2020-11-15