|Table of Contents|

Molecular Evolution of SLC14A2,a Key Gene for Urea Transporters in Marine Mammals(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2022年03期
Page:
79-86
Research Field:
生物学
Publishing date:

Info

Title:
Molecular Evolution of SLC14A2,a Key Gene for Urea Transporters in Marine Mammals
Author(s):
Zeng Fan; Wu Tianzhen; Yu Zhenpeng; Sun Linxia; Guo Tianhui
(School of Life Sciences,Nanjing Normal University,Jiangsu Key Laboratory for Biodiversity and Biotechnology,Nanjing 210023,China)
Keywords:
marine mammals; osmoregulation; SLC14A2 gene; positive selection
PACS:
Q951+.3
DOI:
10.3969/j.issn.1001-4616.2022.03.011
Abstract:
Convergence evolution is the core scientific issue in evolutionary biology. In order to adapt to the hyperosmotic marine environment,independent-originated-marine mammals have evolved the convergent osmoregulation mechanism through producing highly concentrated urine. In this study,the SLC14A2 gene encoding urea transporter was used as a candidate gene for evolutionary analysis. The results revealed that this gene has undergone significant accelerated evolution in marine mammals. Four positively selected sites(35,463,592,598) were detected by at least two maximum likelihood(ML)methods,and these sites were located or near important functional domains. It indicates that marine mammals may produce highly concentrated urine from enhancing the active transport of urea by kidneys,which is consistent with what has been found in the previous physiological studies. Especially,the study identified 6 parallel/convergent evolutionary sites among different groups of marine mammals,which has provided convergent evidence of marine mammals producing highly concentrated urine to adapt to the marine environment at the molecular level. In addition,the positive selection is mainly focused on the evolutionary lineage of cetaceans,which may be related to cetaceans faced greater osmotic pressure than other marine mammals because cetaceans have adapted to fully aquatic life. In this study,the evolutionary analysis of the SLC14A2 gene in marine mammals provides a convergent molecular mechanism of marine mammals to produce highly concentrated urine for adapting to the hypertonic marine environment.

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Last Update: 2022-09-15