|Table of Contents|

Analysis of Key Pathways,Genes and Immune Cell Infiltration in Metastatic Esophageal Squamous Cell Carcinoma Based on Bioinformatics(PDF)

《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

Issue:
2023年02期
Page:
77-84
Research Field:
生物学
Publishing date:

Info

Title:
Analysis of Key Pathways,Genes and Immune Cell Infiltration in Metastatic Esophageal Squamous Cell Carcinoma Based on Bioinformatics
Author(s):
Wang Zhangjiao1; Shen Yong2; Xu Qingxia2
(1.Henan University of Chinese Medicine,The Second Affiliated Hospital of Henan University of TCM,Zhengzhou 450000,China)
(2.Department of Clinical Laboratory,Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital,Zhengzhou 450008,China)
Keywords:
esophageal carcinoma;  biomarker;  immune infiltration;  bioinformatics analysis
PACS:
R735.1
DOI:
10.3969/j.issn.1001-4616.2023.02.010
Abstract:
Esophageal squamous cell carcinoma is one of the common malignant tumors, to systematically and comprehensively explore the characteristics of differentially expressed genes and immune cells in esophageal carcinoma by bioinformatics. Four esophageal cancer data sets were obtained from GEO database, and the differences and gene enrichment were analyzed, and the selected core genes were further explored. A total of 244 differentially expressed genes(DEGs)were screened, including 164 up-regulated genes and 80 down-regulated genes, which were mainly enriched in extracellular region and extracellular space, and related to tumor invasion and metastasis. KEGG results showed that DEGs were mainly enriched in PI3K-Akt signal pathway and extracellular matrix(ECM)receptor interaction signal pathway. And it was found that three hub genes(CXCL8, MMP9 and MMP13)were highly expressed in ESCC. The results of immune infiltration showed that macrophages and resting dendritic cells increased significantly, while mast cells and monocytes decreased significantly. In conclusion, three hub genes and immune infiltrating cells may play an important role in ESCC, and are expected to become potential tumor markers of ESCC and be used in the diagnosis and treatment of ESCC.

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Last Update: 2023-06-15