[1]王薇,周林,唐静,等.纳米TiO_2载体对竹红菌甲素光敏损伤DNA的增敏研究[J].南京师大学报(自然科学版),2011,34(04):60-63.
　Wang Wei,Zhou Lin,Tang Jing,et al.Photosensitization Studies of TiO2 Nanoparticles to Photocleavage Capacility of Hypocrellin A[J].Journal of Nanjing Normal University(Natural Science Edition),2011,34(04):60-63.
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纳米TiO_2载体对竹红菌甲素光敏损伤DNA的增敏研究()
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《南京师大学报（自然科学版）》[ISSN:1001-4616/CN:32-1239/N]

卷:
第34卷
期数:
2011年04期
页码:
60-63
栏目:
化学
出版日期:
2011-12-20

文章信息/Info

Title:
Photosensitization Studies of TiO2 Nanoparticles to Photocleavage Capacility of Hypocrellin A
作者:
王薇1; 2; 周林1; 唐静2; 杨超2; 魏少华2; 冯玉英1; 周家宏1
( 1． 南京师范大学分析测试中心，江苏省生物功能材料重点实验室，江苏南京210046) ( 2． 南京师范大学化学与材料科学学院，江苏南京210046)
Author(s):
Wang Wei1; 2; Zhou Lin1; Tang Jing2; Yang Chao2; Wei Shaohua2; Feng Yuying1; Zhou Jiahong1
1.Analysis & Testing Center,Nanjing Normal University,Nanjing 210046,China
关键词:
竹红菌甲素; 二氧化钛; 光敏损伤; 小牛胸腺DNA
Keywords:
Hypocrellin A; titanic nanoparticles; photocleavage; calf thymus DNA
分类号:
Q523
摘要:
采用溶胶-凝胶法制备竹红菌甲素/二氧化钛纳米粒.结果表明,竹红菌甲素被成功包裹于二氧化钛纳米粒内部.与竹红菌甲素水溶液相比,包裹后的样品紫外吸收峰红移至光疗窗口(600～900 nm),并且在有氧条件下光敏损伤CT-DNA的能力增强.
Abstract:
Hypocrellin A molecules were successfully encapsulated in titanic nanoparticles by sol-gel method． On comparison with free hypocrellin A solution，encapsulated sample extended its absorption into longer wavelength，and showed superior photocleavage capability to calf thymus DNA．

参考文献/References:

［1］ Roy I，Ohulchanskyy T Y，Pudavar H E，et al． Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy［J］． J Am Chem Soc，2003，125( 26) : 7 860-7 865．
［2］ Zhou J H，Zhou L，Dong C，et al． Preparation and photodynamic properties of water-soluble hypocrellin A-silica nanospheres ［J］． Mater Lett，2008，62( 17 /18) : 2 910-2 913．
［3］ Zhou Z Y，Qian S P，Yao S D，et al． Phtoosensitization of a colloidal TiO2 semiconductor system with hypocrellin B［J］． Dyes Pigments，2001，51: 137-144．
［4］ Xu S J，Shen J Q，Chen S，et al． Active oxygen species ( 1O2 ，O· － 2 ) generation in the system of TiO2 colloid sensitized by hypocrellin B［J］． J Photochem Photobio B，2002，67( 1) : 64-70．
［5］ Kathiravan A，Renganathan R． Photoinduced interaction between colloidal TiO2 nanoparticles and calf thymus-DNA［J］． Polyhedron，2009，28: 1 374-1 378．
［6］ Zhou Z X，Qian S P，Yao S D，et al． Electron transfer in colloidal TiO2 semiconductors sensitized by hypocrellin A［J］． Radiat Phys Chem，2002，65( 3) : 241-248．
［7］ Zhou L，Dong C，Wei S H，et al． Water-soluble soft nano-colloid for drug delivery［J］． Mater Lett，2009( 63) : 1 683- 1 685．
［8］ Zhou L，Zhou J H，Dong C，et al． Water-soluble hypocrellin A nanoparticles as a photodynamic therapy delivery system［J］． Dyes Pigments，2009，82: 90-94．
［9］ 魏少华，卢珊，季春． p-HPcZn 与CT DNA 相互作用［J］． 应用化学，25( 7) : 763-767．
［10］ Zhou L，Liu J H，Wei S H，et al． DNA combining and photocleaving preoperities of photosensitizer-encapsulated silica nanoparticles ［J］． Monatsh，2009，140: 1 167-1 170．
［11］ Xia S Q，Zhou J H，Chen J R， et al． A tyrosine-modified hypocrellin B with affinity for and photodamaging ability towards calf thymus DNA［J］． Chem Comm，2003( 23) : 2 900-2 901．

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金( 20603018) ．通讯联系人: 周家宏，博士后，教授，研究方向: 光化学与功能材料的研究． E-mail: zhoujiahong@ njnu． edu． Cn
更新日期/Last Update: 2013-03-21