[1]刘斯斯,李伟丽,李国梁,等.早期咖啡因暴露对成年小鼠苦味适应的影响[J].南京师大学报(自然科学版),2013,36(01):79-84.
 Liu Sisi,Li Weili,Li Guoliang,et al.The Influence of Bitter Adaptation in Adulthood Induced by Early Postnatal Exposure to Caffeine[J].Journal of Nanjing Normal University(Natural Science Edition),2013,36(01):79-84.
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早期咖啡因暴露对成年小鼠苦味适应的影响()
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《南京师大学报(自然科学版)》[ISSN:1001-4616/CN:32-1239/N]

卷:
第36卷
期数:
2013年01期
页码:
79-84
栏目:
生命科学
出版日期:
2013-03-31

文章信息/Info

Title:
The Influence of Bitter Adaptation in Adulthood Induced by Early Postnatal Exposure to Caffeine
作者:
刘斯斯1李伟丽1李国梁1陈梦玲2张根华12
(1.苏州大学医学部基础医学与生物科学学院,江苏 苏州 215123) (2.常熟理工学院食品与生物工程学院,江苏 常熟 215500)
Author(s):
Liu Sisi1Li Weili1Li Guoliang1Chen Mengling2Zhang Genhua12
(1.College of Preclinical Medicine and Biological Science,Soochow University,Suzhou 215123,China) (2.College of Biology and Food Science,Changshu Institute Technology,Changshu 215500,China)
关键词:
咖啡因小鼠TBPs偏好适应
Keywords:
caffeinemouseTBPspreferenceadaptation
分类号:
Q189
摘要:
咖啡因是一种典型的苦味刺激物,常作为一种心理刺激药物被广泛应用.通常而言,人们对咖啡因的感知是厌恶的,但这种感知可以被后天的经历所影响.我们的实验结果表明,在小鼠出生后早期阶段对其进行慢性咖啡因暴露,可以影响其成年阶段对咖啡因的感知模式,并提高其对咖啡因的厌恶阈值,即早期咖啡因暴露使成年小鼠对咖啡因的苦味适应性增强.
Abstract:
Caffeine is a prototypic bitter stimulus and is consumed as psychoactive stimulant widely.Customarily,people present aversion to caffeine.But the taste preferences can be affected by postnatal experience.Our research indicates that chronic administration of caffeine for mice at early developmental stage may influence the adult caffeine sensory.According to the behavioral test,we observed that the avoid thresholds for caffeine had been increased.Early postnatal exposure to caffeine increases the bitter adaptation in adulthood of ICR mice.

参考文献/References:

[1] Drewnowski A,Henderson S A,Barratt-Fornell A.Genetic taste markers and food preferences[J].Drug Metab Dispos,2001,29(4):535-538.
[2]Schaal B,Marlier L,Soussignan R.Human foetuses learn odours from their pregnant mother’s diet[J].Chem Senses,2000,25(6):729-737.
[3]Smriga M,Kameishi M,Torii K.Brief exposure to NaCl during early postnatal development enhances adult intake of sweet and salty compounds[J].Neuroreport,2002,13(8):2565-2569.
[4]Mennella J A,Forestell C F,Morgan L.Early milk feeding influences taste acceptance and liking during infancy[J].Am J Clin Nutr,2009,90(3):780S-788S.
[5]Sclafani A.Oral,post-oral and genetic interactions in sweet appetite[J].Physiol Behav,2006,89(4):525-530.
[6]Beauchamp G K,Mennella J A.Flavor perception in human infants:development and functional significance[J].Digestion,2011,83(1):1-6.
[7]Forestell C A,Mennella J A.Early determinants of fruit and vegetable acceptance[J].Pediatrics,2007,120(6):1247-1254.
[8]Harder D B,Maggio J C,Whitney G.Assessing gustatory detection capabilities using preference procedures[J].Chem Senses,1989,14(4):547-564.
[9]Glendinning J I,Gonzalez N A.Gustatory habituation to deterrent compounds in a grasshopper:concentration and compound specificity[J].Anim Behav,1995,50(4):915-927.
[10]陆梦,张莉,丁雪瑞,等.咖啡因对小鼠空间学习记忆及体重的影响[J].西安交通大学学报:医学版,2010,31(5):648-650.
[11]张根华.甜味偏好可塑性的味觉细胞学基础[D].杭州:浙江工商大学食品与生物工程学院,2007.
[12]Laska M,Rivas B R M,Hernandez S L T.Gustatory responsiveness to six bitter tastants in three species of nonhuman primates[J].J Chem Ecol,2009,35(5):560-571.
[13]Bachmanov A A,Li X,Reed D R,et al.Positional cloning of the mouse saccharin preference(Sac)locus[J].Chem Senses,2001,26(7):925-933.
[14]Smith P F,Smith A,Miners J.The safety aspects of dietary caffeine:report from the Expert Working Group[R].Australia:New Zealand Food Authority,2000.
[15]Keast R S J,Breslin P A S.Cross adaptation and bitterness inhibition of L-tryptophan,L-phenylalanine and urea:further support for shared peripheral physiology[J].Chem Senses,2002a,27(2):123-131.
[16]Zhao F L,Lu S G,Herness S.Dual actions of caffeine ovoltage-dependent currents and intracellular calcium in taste receptor cells[J].Am J Physiol Regul Integr Comp Physiol,2002,283(1):R115-R129.
[17]Rosenzweig S,Yao W T,Dasso M,et al.Possible novel mechanism for bitter taste mediated through cGMP[J].J Neurophysiol,1999,81(4):1661-1665.
[18]Meyerhof W,Batram C,Kuhn C,et al.The molecular receptive ranges of human TAS2R bitter taste receptors[J].Chem Senses,2010,35(2):157-170.
[19]Glendinning J I,Browm H,Capoor M,et al.A peripheral mechanism for behavioral adaptation to specific“bitter”taste stimuli in an insect[J].J Neurosci,2001,21(10):3688-3696.

备注/Memo

备注/Memo:
收稿日期:2012-05-30.
基金项目:国家自然科学基金项目资助(NSFC31140086、NSFC31200812).
通讯联系人:张根华,教授,博士,研究方向:食品安全与味觉细胞生物学.E-mail:zgh@cslg.cn
更新日期/Last Update: 2013-03-31